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A 2025 study showed that MAO-A levels are very high in varicose veins, adding to the oxidative stress by producing hydrogen peroxide and aldehydes

Additionally, it is widely recognized that nanoparticles smaller than 500 nm can evade the reticuloendothelial system (RES), thereby prolonging their circulation time 47

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Antiangiogenic drugs may address both vascular and neuronal dysfunction, offering a potential avenue for disease-modifying treatments

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